NR3C2 and Hyperkalemia: However, inhibition of the RAAS with ACEI, ARB, direct renin inhibitors (DRI) or MR antagonists especially in dual or triple combination, increased the risk of hyperkalemia in patients with heart failure (HF), or chronic kidney disease (McMahon, 2001; Sica, 2002; Palmer, 2004; Weir and Rolfe, 2010).