APP and Alzheimer disease: Of the three zones examined, NF+ DNs were most common at the plaque edge in APP/PS1 mice (54.6 ± 2.2%) followed by Tg2576 mice (53.2 ± 2.0%), end-stage AD (40.3 ± 1.7%), and preclinical AD cases (33.4 ± 1.9%; mean ± SEM).