In preclinical AD cases and transgenic mice, Aβ plaque-associated DNs are predominantly labeled with antibodies to neurofilament triplet proteins (NFs) and α-internexin, whereas in end-stage AD, subgroups of DNs contain NFs, abnormal tau protein, or a rim of NFs around a tau core (Benzing et al., 1993; Su et al., 1996; Dickson et al., 1999, 2005). The gene discussed is MAPT; the disease is Alzheimer disease.