Both NF+ (Figure 5A) and CR+ (Figure 5B) neurites exhibited comparable pronounced neurite density loss in the plaque core in end-stage AD, preclinical AD, APP/PS1, and Tg2576 cases (p < 0.01, one-way ANOVA, Dunnett’s post hoc tests). The gene discussed is CALB2; the disease is Alzheimer disease.