PRKN and Parkinson disease: The most important and widely accepted monogenically inherited Parkinson's disease genes are α-synuclein (SNCA) and leucine-rich repeat kinase 2 (LRRK2) for late-onset disease and Parkin (PARK2), oncogene DJ1 (DJ1) and PTEN Induced Putative Kinase 1 (PINK1) for early onset (Coppede, 2012).