SLC1A2 and juvenile Huntington disease: MiR-124a is another miRNA which targets BACE1 and has an additional role in excitotoxicity via regulating the glutamate transporter EAAT2 and is itself affected by the Huntington's disease associated transcription factor REST (Marti et al., 2010; Smith et al., 2011; Morel et al., 2013).