ATXN3 and amyotrophic lateral sclerosis: MARCH5 also plays a role in the degradation of mSOD1 associated with amyotrophic lateral sclerosis (Yonashiro et al., 2009), in the disposal of mutated ataxin-3 causative for Machado–Joseph disease (Sugiura et al., 2011) as well as the clearance of S-nitrosylated MAP1B-light chain 1 linked to neuronal degeneration (Yonashiro et al., 2012).