MIF is a newly arrived player in the air pollution scenario, is an active participant in innate and acquired immunity (Savaskan et al., 2012), its association with the production of several inflammatory mediators including IL-6, TNF-α, and IFN-γ, and the identification of CSF MIF as a biomarker in AD and mild cognitive impairment patients (MCI) (Popp et al., 2009; Craig-Schapiro et al., 2011) has a great impact in air pollution-related brain effects. Here, TNF is linked to Cognitive impairment.