Since IL-2 is also required for regulating the Th2 cytokine response during T-cell activation and participates in multifactorial autoimmune responses (Wang et al., 2009; Baine et al., 2013), the issue of autoimmunity to CNS components warrants full investigation in exposed children especially those with extensive white matter hyperintense lesions (Calderón-Garcidueñas et al., 2008b, 2012b). This evidence concerns the gene IL2 and Autoimmunity.