MIF and stroke disorder: MIF participates in the induction of neural stem/progenitor cells (Ohta et al., 2012), the protection of mice female brains after experimental stroke (Turtzo et al., 2013), the mediation of the antidepressant action of exercise (Moon et al., 2012), and of key importance for this work, MIF plays a key role in neuroinflammatory responses (Savaskan et al., 2012; Cox et al., 2013).