MIF and early-onset autosomal dominant Alzheimer disease: Moreover, in the scenario of air pollution and the early hallmarks of Alzheimer's disease (AD) in Mexico City children (Calderón-Garcidueñas et al., 2008a, 2012a), two key issues are of utmost interest to us: the increased concentrations of MIF in the cerebro-spinal-fluid (CSF) of AD patients and the capacity of MIF to enhance the ability of the tau/Aβ42 ratio to discriminate cognitively normal vs. mildly demented patients (Lee et al., 2008; Bacher et al., 2010; Craig-Schapiro et al., 2011).