PET/CT may play an important role in MPNST management, as increased FDG uptake is associated with malignant transformation, and PET/CT has 72% specificity for diagnosis of malignancy.19 In addition, whole-body MRI adequately assesses tumor burden in patients with NF1, and can allow visualization of tumors not observed on physical examination. This evidence concerns the gene NF1 and malignant peripheral nerve sheath tumor.