VEGFA and neoplasm: Al Nedawi et al. showed that tumour specific growth receptor EGFRvIII can be transferred between glioma cells by EVs, leading to transfer of oncogenic activity, such as activation of transforming signalling pathways (MAPK and Akt), changes in expression of EGFRvIII-regulating genes (VEGF, Bcl-xL, p27), morphological transformation and increase in anchorage-independent growth capacity.75