BSG and neoplasm: Another example of EV-mediated protein delivery in tumour progession has been described by Sidhu et al. 77 The authors showed that extracellular matrix metalloproteinase inducer (EMMPRIN or CD147) is released from the surface of lung carcinoma cells via EVs which rapidly break down to release bioactive EMMPRIN, that stimulates matrix metalloproteinase expression in fibroblasts, thereby facilitating tumour invasion and metastasis.77