However, a DGAT2 antisense oligonucleotide increased levels of hepatic free fatty acids, lipid oxidant stress, lobular necroinflammation and fibrosis in mice fed with a methionine choline-deficient (MCD) diet that generates inflammation and fibrosis with hepatic steatosis, whereas hepatic triglyceride content decreased [32]. The gene discussed is DGAT2; the disease is fatty liver disease.