SOCS3 and myeloproliferative neoplasm: Moreover, using MSP primers close to the TSS in the 5′UTR (Figure S3), we and others showed infrequent methylation of SOCS3 in MPN (this study, 0%; Fourouclas et al., 27%; Teofilli et al., 13.5% and Fernández-Mercado et al., 7.7%) [21, 22, 29], in contrast to frequent methylation of 41.1% samples when MSP primers inside the translated exonic DNA sequence were used [20].