SOCS3 and myeloproliferative neoplasm: To account for the discrepancy among the frequency of methylation of SOCS1, SOCS2 and SOCS3 in MPN, we have mapped the MSP primers used in different studies onto the gene map of SOCS1, SOCS2 and SOCS3 (Figures S1–3; Table 1) and derived the following observations.