We investigated correlations between EGFR expression in resected ESCC tissues and survival of ESCC patients and found that the 5-year OS and DFS rates of patients with EGFR expression were 15.0% and 14.4%, respectively, and the median survival times were 16.0 months and 11.6 months. Here, EGFR is linked to esophageal squamous cell carcinoma.