The SYT-SSX1 fusion occurs in ~ 2/3 of cases [7] and the SYT-SSX fusion type correlates with tumor histology with the majority of monophasic and biphasic synovial sarcomas harboring the SYT-SSX2 and SYT-SSX1 fusions respectively [8]. The gene discussed is SSX2; the disease is synovial sarcoma.