Increased incidence occurring during and after pregnancy, as well as following use of oral contraceptives, the preponderance of women of reproductive age in many series, anecdotal reports of spontaneous tumour regression during menopause, expression of oestrogen beta receptor and reports of tumour regression with anti-oestrogen treatment are all factors which indicate a potential aetiological role for female sex hormones [1,2]. Here, ESR2 is linked to neoplasm.