Taken together, our results suggest that the differential effects of AD 198 and PEP005 on tumor B cells are mediated by their distinct effects on multiple signaling pathways, including PKCδ, PKCε, and PKCα translocation (Figure 5A), and ERK, p38 and JNK phosphorylation (Figure 6A). The gene discussed is MAPK8; the disease is neoplasm.