No prognostic significance could be seen for cytoplasmic 4EBP1 (data not shown), but the variable 4EBP1cytoplasm ≥ nucleus was an independent prognostic factor, predicting increased risk of distant recurrence and breast cancer death (Figure 4e), especially among patients with PgR-expressing tumours (Figure 4f). The gene discussed is PGR; the disease is neoplasm.