Consequently, phosphorylated 4EBP1 (p4EBP1) has been generally accepted as a marker of activated mTOR signalling and high levels in tumours have been associated with a worse outcome in several malignancies, whereas nonphosphorylated 4EBP1 has been considered a tumour suppressor [10]. The gene discussed is EIF4EBP1; the disease is neoplasm.