The prediction models for eczema had poor performance, suggesting either that disruption in skin barrier function may be more important in the pathogenesis of eczema than IgE-mediated mechanisms or that other allergens not available on the chip may be predictive of eczema (e.g., Staphylococcus aureus enterotoxins) 23. The gene discussed is IGHE; the disease is Eczematoid dermatitis.