Focal Cdx2 expression was significantly more frequent in colorectal cancers with mucinous histology (p = 0.0053), higher tumor grade (p = 0.0002), more advanced pT stage (p = 0.0166), with perineural invasion (p = 0.0228), and in those receiving adjuvant therapy (p = 0.0058). The gene discussed is CDX2; the disease is neoplasm.