FGF2 and neoplasm: The angiogenic switch is a complex process that involves the elaboration by the avascular tumor of cytokines and growth factors including vascular endothelial growth factor (VEGF), fibroblast growth factor (bFGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), and a variety of angiopoietins [1,11-13].