Given the similarities of the effect of NSC109268 on mediating cellular sensitization to CP in yeast and cancer cell lines, given also the high degree of conservation of DNA repair pathways and the availability of a collection of deletion mutants of non-essential yeast genes, yeast must be considered a valuable model to study the targeted pathway(s) of NSC109268 that are relevant for CP sensitivity [16]. The gene discussed is CP; the disease is cancer.