In the present study, we have demonstrated that bone marrow-derived fibroblasts in the obstructed kidney express CCR2 and genetic disruption of CCR2 suppresses the accumulation of bone marrow-derived fibroblasts expressing CD45 and procollagen I or PDGFR-β and attenuates the degree of renal fibrosis. This evidence concerns the gene CCR2 and renal fibrosis.