Taken together, our results indicate that the combination of Rapamycin/Cl-1040/17-AAG decreases tumor metastasis, most likely via the transcriptional suppression of Slug, which is concomitantly expressed by the activation of the MAPK/ERK, PI3K/Akt/mTOR, and Hsp90/AR. The gene discussed is SNAI2; the disease is neoplasm.