In other mouse tumor systems, CD8+ and CD4+ T-cells have been shown to confer not only cytotoxic activity (CD8+) and help for other T-cells (CD4+), they also orchestrate the immune response against tumor cells by activating cells of the innate immune system, i.e. NK cells and macrophages, in an antigen-dependent manner [42,43]. The gene discussed is CD4; the disease is neoplasm.