However, choosing unmutated c-MYC as a T-cell target bears two major obstacles: first, T-cells specific for c-MYC may be present only at low affinity and frequency or may be even non-existent due to negative selection in the thymus; secondly, induction of c-MYC specific T-cells may cause autoimmunity to highly proliferative tissues such as the hematopoietic system or the enteral mucosa. Here, MYC is linked to Autoimmunity.