A noteworthy protein complex involved BCR-ABL and the adaptor protein GRB2, the phosphatidylinositol-5-phosphatase INPPL1 (SHIP-2) and the tyrosine phosphatase UBASH3B (STS-1), which have been previously described in CML (Figure 3B) [37]. This evidence concerns the gene INPPL1 and chronic myelogenous leukemia, BCR-ABL1 positive.