MARK2 and chronic myelogenous leukemia, BCR-ABL1 positive: This was particularly the case for the phosphotyrosine signature of bosutinib in BV-173 cells (Figure 5A), which suggests either a weak overall potency or that much of the net effect of bosutinib in these cells can be attributed to inhibition of serine/threonine kinases, which is supported by previous phosphoproteomics studies in CML (Bantscheff, Nat.Biotech., 2007; Winter, NCB, 2012).