CD4 and cryohydrocytosis: To determine the impact of serum HCV titers on the function of global CD4+ and CD8+ T-cells in CHC patients, we divided the CHC patients into 3 groups: HCV-n (negative), HCV-l (low) (104-106 IU/ml RNA), and HCV-h (high) (106-108 IU/ml RNA) (Figure 1A).