CASP1 and cryohydrocytosis: Interestingly, the expression levels of 5 apoptosis-related genes death-associated protein kinase 1 (DAPK1), pleckstrin homology-like domain family A member 1 (PHLDA1), pleckstrin homology-like domain family A member 2 (PHLDA2), CASP1, and NLR family pyrin domain-containing 3 (NLRP3) in CD4+ T-cells from CHC patients were positively correlated with ALT, AST, TBIL, and DBIL values (Figure 6A).