Univariate analysis revealed that liver metastasis (P = 0.006), metastasis at presentation (P = 0.018), two or more metastasis sites (P = 0.0001), anemia (P < 0.0001), higher baseline LDH level (P = 0.0002), higher baseline EBVDNA level (P < 0.0001), higher baseline CRP (P < 0.0001), and CRP kinetics (elevated CRP, normalized CRP and non-normalized CRP, P = 0.0001) were considered adverse factors for overall survival (Table 2). This evidence concerns the gene CRP and anemia.