EGFR and hepatocellular carcinoma: In another paper, inducible Xmrk, a naturally occurring mutated form of the EGFR isoform EGFRb, was shown to produce a high incidence and early onset of HCC in transgenic zebrafish [30], and experiments with the inhibitors PD98059 (MEK/Erk inhibitor) and nicotinohydrazide (Stat 5 inhibitor) demonstrated that this model was useful for drug screening.