TP53 and hepatocellular carcinoma: However, the overexpression of src in the p53 mutant fish resulted in the development of steatosis, hyperplasia, dysplasia, and HCC; moreover, sarcomatoid HCC characterized by pleomorphic spindle tumor cells growing in haphazard, fascicular patterns was observed in three out of five cases of HCC (Figure 6B2 to B6).