IL18 and cancer: However, no significant association between -607C/A polymorphisms in IL-18 gene promoter and cancer risk was observed under the allelic model(A vs C:OR =1.088, 95% CI: 0.987,1.200; Pheterogeneity=0.003), homozygous model(AA vs CC:OR =1.139, 95% CI: 0.948, 1.369; Pheterogeneity=0.023), and recessive model (AA vs. CC/CA: OR =0.995, 95% CI: 0.851, 1.163; Pheterogeneity=0.025) (shown in Table 2).