The last layer of stringency eliminated 52 genes that were less than two-fold up (n = 20) or down (n = 32) in human-mouse lymphoma counterparts (Figure 2D right), resulting in 60 genes (40 up and 20 down), referred to as DMB genes (human DLBCL & mouse iMyc B-cell lymphoma genes) henceforth, listed in Table 1. This evidence concerns the gene HLA-DMB and diffuse large B-cell lymphoma.