Interphase cytogenetic studies for del(13q14) (D13S319), del(6q22.3) (c-MYB), del(11q22.3) (ATM), del(17p13.1) (TP53), +3 (BCL6), +8 (MYC), +12 (centromere) and t(11;14) (CCND1-IGH fusion) revealed no additional genomic lesions common in CLL. The gene discussed is CCND1; the disease is B-cell chronic lymphocytic leukemia.