EEF2 and neoplasm: The two major findings of this study are (i) that hypoxia accounts for the modification of the immunoproteome as evidenced by the detection of circulating aAb directed against TAA undetectable in tumor cells cultured under normoxic conditions, and (ii) that the hypoxia-mediated stimulation of eEF2 phosphorylation accounts for the development of an early aAb response to colorectal cancer development.