Our findings suggest that pre-eclamptic women with additional predisposing risk factors and proteinuria of 300-499mg/24h have more severe hypertension, early deliveries and SGA infants above those of women managed as out-patients (GH and CHT); those with proteinuria ≥500mg/24h should be considered to be at substantially greater risk of pregnancy complications than women with proteinuria of 300 mg/24h. This evidence concerns the gene SLC5A7 and Hypertension.