EIF2AK4 and Hepatic steatosis: Of particular relevance, serum triglyceride levels were doubled in Gcn2;db DKO mice (Fig. 4C) compared to the very high levels seen in db/db mice whereas the elevated hepatic triglycerides (Fig. 4D) and extreme liver steatosis typically seen in db/db mice was substantially ameliorated (Fig. 4E–G compared to Fig. 4F-H).