Several lipid droplet proteins including the PAT family (perilipin 1, perilipin 2/ADRP, and perilipin 3/TIP47) and CIDE family (CIDEA, CIDEB, and CIDEC/FSP27) were first identified in adipose tissue and shown to orchestrate storage and retrieval of triglycerides [7], [8] and mutations in some of these genes result in lipodystrophy and insulin resistance [9]. Here, CIDEC is linked to Insulin resistance.