In addition, in various tumor models, including C26 colon carcinoma cells [12], [13], Lewis lung carcinoma [14], TBJ neuroblastoma [15], [16], and B16F10 melanoma cells [17], [18], tumor cell lines genetically engineered to overexpress IL-27 showed growth inhibition, in vivo, compared to the IL-27-negative parental cell lines. The gene discussed is IL27; the disease is melanoma.