GHRL and Other metabolic disease: In the present study, we showed that 1) BOF persistently decreased food intake and body weight gain; 2) BOF consistently decreased blood pressure without affecting heart rate; 3) BOF decreased WAT weight and adipocyte hypertrophy, and ameliorated the adipocytokine dysregulation in WAT; 4) BOF increased UCP-1 mRNA expression in BAT and also the rectal temperature and 5) BOF decreased the short-term food intake and the plasma acylated-ghrelin level in KKAy mice, a model of human metabolic disorders with visceral obesity, T2DM, dyslipidemia and hypertension.