Mutation of RyR1 or RyR2 causes functional disorders of receptors and induces malignant hyperthermia, central core disease (CCD), catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular dysplasia type 2. Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia 1.