RYR1 and catecholaminergic polymorphic ventricular tachycardia 1: Mutation of RyR1 or RyR2 causes functional disorders of receptors and induces malignant hyperthermia, central core disease (CCD), catecholaminergic polymorphic ventricular tachycardia, and arrhythmogenic right ventricular dysplasia type 2.