Combining these findings, where miR-29b is a negative regulator of metastasis and targets key player of metastasis MMP-2, and HAG induces miR-29b and suppresses MMP-2 expression (Tables 1 and 2; Figures 1, 2 and S4), we asked the question if HAG functionally suppresses metastasis of colon cancer cells. The gene discussed is MMP2; the disease is colonic neoplasm.