This is a clear indication that MMP-2 is a key factor in the regulation of cell migration, however it should not be ruled out that other ECM degrading MMPs such as MMP-1, MMP-7, MMP-9 and MMP-13 have been shown be associated with Colorectal cancer progression [37], [41], [42], [43], [44]. The gene discussed is MMP1; the disease is colorectal cancer.