Briefly, we conclude that the group induced to DM presented alterations to the Achilles tendon with structural and vascular changes that are compatible with the process of chronic tendinopathy, since, in the presence of hyperglycemia important changes occurred, such as an increment of mast cells, significant increase in the number of blood vessels in the peri- and intratendinous regions, as well as increased cross-sectional area of the vessels and increased expression of type 1 collagen, VEGF and NF-κB when compared to tendons of healthy animals. Here, NFKB1 is linked to diabetes mellitus.