Because of the low expression of IL-10 in freshly isolated control PBMCs (Figure S2), we stimulated control PBMCs with IFN-α, a pivotal cytokine upregulated in most SLE patients [23], to mimic SLE PBMCs and incubated them with the MAPK inhibitors specific to ERK (PD 98059), JNK (SP 600125) or p38 (SB 203580), respectively. This evidence concerns the gene IL10 and systemic lupus erythematosus.