A number of genetic polymorphisms in the IL10 promoter region have been reported [26]–[30], in particular, three SNPs shown in Figure 1D located at −1082 (rs1800896, C/T), −819 (rs1800871, G/A) and −592 (rs1800872, G/T) have been inconsistently associated with IL-10 production levels and risk of SLE (reviewed in [18], [19]). This evidence concerns the gene IL10 and systemic lupus erythematosus.