Recent genome-wide association (GWA) and follow-up replication studies in European ancestry have identified an association between the minor allele of rs3024505, a SNP located at 1 kb downstream of IL10, and increased risk for SLE [3], inflammatory bowel disease (IBD) including both Crohn's disease (CD) [4] and ulcerative colitis (UC) [5], [6], and decreased risk for type 1 diabetes [7], [8]. Here, IL10 is linked to irritable bowel syndrome.