In the largest EA dataset, rs3024505 located at 1 kb downstream of IL10 exhibited the strongest association with SLE (minor allele frequency of 18.2% in cases vs. 14.8% in controls, P = 2.7×10−8, OR [95%CI] = 1.30 [1.19–1.43]), which exceeded the GWAS significance level of P<5×10−8 (Table S1). Here, IL10 is linked to systemic lupus erythematosus.