Consistently, the SNP (rs3122605) we identified that tags the SLE-risk haplotype in EA ancestry and confers genetic effect on IL10 expression is located at 9.2 kb upstream of IL10. According to the ENCODE Project, rs3122605, rs3024505, rs3024493 and rs61815643 were located within DNasel hypersensitive and transcription factor binding sites in at least one cell type (as shown in UCSC genome browser), suggesting that each of them may affect gene expression through interaction with regulatory elements. Here, IL10 is linked to systemic lupus erythematosus.