Consistently, dose-dependent association of the risk allele with elevated IL10 expression was also observed in patients with SLE at both mRNA (n = 58; P = 6.4×10−6, R2 = 0.31) and protein (n = 132; P = 1.4×10−6, R2 = 0.16) levels (Figure 2). The gene discussed is IL10; the disease is systemic lupus erythematosus.