Of them, three imputed SNPs (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), which were in tight linkage disequilibrium (LD, r2>0.9) with the genotyped SNP rs3024505, were strongly associated with SLE and remained significant after Bonferroni correction (rs3122605: P = 1.3×10−8, OR = 1.34 [1.21–1.48]; rs3024493: P = 5.0×10−8, OR = 1.29 [1.18–1.42]); rs3024495: P = 1.0×10−7, OR = 1.29 [1.17–1.41]) (Figure 1B and Table S1). This evidence concerns the gene IL10 and systemic lupus erythematosus.