In addition to confirming the previously reported association with SLE at the IL10 3′ downstream SNP (rs3024505) in European Americans, we identified a SLE-associated risk haplotype, defined by the minor alleles of four SNPs in tight LD, rs3024505, rs3024495, rs3024493 and rs3122605, which could best explain the association with SLE and capture underlying causal variant(s) within the IL10 gene cluster in EA ancestry. Here, IL10 is linked to systemic lupus erythematosus.