Our current study has identified RE and RE9a as a novel positive transcriptional regulators of Alox5. Interestingly, the data indicate that regulation of Alox5 by RE9a is indirect, as no peak of RE9a binding was observed in the Alox5 promoter region when performing ChIP-chip on RE9a-leukemia cells [18], and no RUNX1 binding motifs are present in the RE9a-responsive region of the Alox5 promoter (Figure 2). Here, ALOX5 is linked to leukemia.