RARA and acute myeloid leukemia: To determine whether the self-renewal defects observed in Alox5-/- cells were specific to RE9a or were more broadly applicable, we performed similar replating assays using the oncogenic fusion proteins MLL-AF9, resulting from t(9;11) and most frequently occurring in acute monoblastic leukemia (AML M5) [43], and PML-RARα, resulting from t(15;17) and observed in acute promyelocytic leukemia (APL/AML M3) [44].