Although IFN-γ, IL-10, and TNF-α responses remained intact in the MLN and spleen late during infection of CXCR3-deficient mice, a significant decrease in IL-12 production was observed in the MLN (Fig. 6A) and spleen (Fig. 6B) of Cxcr3−/− mice. The gene discussed is CXCR3; the disease is infection.