For example, miR-125b is reported to promote hepatocellular carcinoma cell apoptosis by targeting Bcl-2, an anti-apoptotic protein [57], while miR-125b inhibits apoptosis of Hela cells and human immortalized myelogenous leukemia K562 cells by targeting pro-apoptotic proteins, Bak1, Mcl1 and p53 [58]. The gene discussed is BAK1; the disease is myeloid leukemia.