Further evidence for the pro-apoptotic role of Type I IFN and Bak in HIV-1 infection was revealed by our finding that ex vivo expression of the IFNα-induced genes [26] in PBMC from HIV-1-infected patients was increased and positively associated with Bak expression levels, CD95/Fas-mediated T cell apoptosis sensitivity and high viral loads, while it correlated inversely with CD4+ T cell counts. This evidence concerns the gene CD4 and HIV-1 infection.