Compared to FTD and ALS cases lacking the C9ORF72 expansion, c9FTD/ALS is marked by abnormal cerebellar pathology, such as inclusions composed of (GGGGCC)exp RAN proteins [3, 25], as well as inclusions negative for TDP-43, but immunopositive for p62, ubiquitin, and various ubiquitin-binding proteins [1, 28]. Here, RAN is linked to amyotrophic lateral sclerosis.