In fact, it was demonstrated that both AdipoRs are expressed in COPD and tumor lung [33,59]; moreover a recent study demonstrated a higher expression of AdipoR1 than AdipoR2 in lung tissues from COPD and non small cell lung cancer (NSCLC) suggesting a specific signaling pathway of adiponectin in this disease [60]. The gene discussed is ADIPOR2; the disease is non-small cell lung carcinoma.