In fact, it was demonstrated that both AdipoRs are expressed in COPD and tumor lung [33,59]; moreover a recent study demonstrated a higher expression of AdipoR1 than AdipoR2 in lung tissues from COPD and non small cell lung cancer (NSCLC) suggesting a specific signaling pathway of adiponectin in this disease [60]. This evidence concerns the gene ADIPOQ and chronic obstructive pulmonary disease.