Specifically, several genes may represent targets for further research, including CBLC or IRS2, which influence breast cancer survival; transcription factors RPS6KA2 and RPS6KA6, the interaction among MCM/CDC and ORC cell cycle control genes, and DUSP1, DUSP9, RIPK2 and MAPK9 in the onset of hepatocellular carcinoma; or cell-cycle genes BRSK1, WEE1, CDC25C, and the transcription factor SPIB in colorectal adenoma development. The gene discussed is IRS2; the disease is colorectal adenoma.