In addition, and more importantly, gene expression profile revealed that DHH-RHEBL1-positive patients showed a specific gene expression signature, with 518 and 596 genes being significantly overexpressed when compared to patients harboring only the CBFA2T3-GLIS2 fusion transcript (P<0.05) and CN-AML patients (P<0.05), respectively. Here, RHEBL1 is linked to acute myeloid leukemia.