GLIS2 and acute myeloid leukemia: Firstly, we analyzed the expression level of the two genes involved in the fusion transcript and we found that the expression of both DHH and RHEBL1is significantly enhanced in the DHH-RHEBL1-positive patients as compared with patients harboring only CBFA2T3-GLIS2 fusion (P=0.007 and P=0.009 respectively) and with the other CN-AML cases (P=0.0005 and P=0.043, respectively) (Figure 2A).