Remarkably, exposure to epigenetic drugs (TSA alone or in combination with 5-aza-dC) resulted in increased H2AFZ levels in PCa cells and these results were corroborated by ChIP, which demonstrated an enrichment of histone activating marks, such as AcH3 and H3K4me2, in the TSS proximity. This evidence concerns the gene H2AZ1 and posterior cortical atrophy.