Rcan1 thus appears to promote atherosclerosis without interfering with CN activity, perhaps through its interaction with other Rcan1-interacting proteins implicated in gene activation, such as Raf-1 (Cho et al, 2005), 14-3-3 (Abbasi et al, 2006) and NF-kB-inducing kinase (Lee et al, 2008). The gene discussed is RCAN1; the disease is atherosclerosis.