Rcan1 additionally plays an essential role in the migration of VSMCs in response to angiotensin II stimulation; moreover, Rcan1 genetic ablation in the mouse confers resistance to abdominal aortic aneurysm and to neointima formation in a restenosis model (Esteban et al, 2011). This evidence concerns the gene RCAN1 and abdominal aortic aneurysm.