TBX1 and neoplasm: As shown in Figure 1D, blockade of MHC class I significantly decreased the lysis of SW480 cells, reinforcing the idea that stimulation of PBMCs with recombinant yeast-brachyury–treated DCs induces brachyury-specific CTLs that are capable of lysing brachyury-positive tumor cells in an MHC class I–restricted manner.