Up to date, several transcription factors have been identified that are able to drive tumor EMT; one distinction that has been reported between brachyury and others, incuding TWIST1, SNAIL and SLUG, is the more selective expression of brachyury in tumors vs. normal tissues [6, 21], which makes it an attractive target for anti-tumor interventions. The gene discussed is SNAI2; the disease is neoplasm.