Although transcription factors, such as brachyury, would be expected to be found only in the nuclear compartment, short fragments of brachyury (9-15 amino acids long) are processed and transported to the surface of the tumor cell in the context of MHC class I and class II molecules to activate brachyury-specific CD8+ and CD4+ T cells, respectively. Here, TBX1 is linked to neoplasm.