Several episodes of hypoglycaemia after the initiation of anti-TNF-alpha therapy have been reported in two women with rheumatoid arthritis, one also affected by type 2 diabetes [20] and the other by latent autoimmune diabetes of adults (LADA) [21], for which it was necessary to reduce, in both of them, the doses of exogenous insulin [20,21]. This evidence concerns the gene TNF and type 2 diabetes mellitus.