In fact, a 55 year old woman suffering from the age of 30 from T1DM and afflicted by rheumatoid arthritis 3 years after had several episodes of severe hypoglycemia following the administration of etanercept and adalimumab, probably due to an increased sensitivity to the action of insulin due to blockade of the action of TNF-alpha in adipose tissue level [19]. This evidence concerns the gene INS and type 1 diabetes mellitus.