Of the genes listed in Tables 1 and 2, eight genes (ACAP2, GSTT1, NRP1, PAK2, SET, SSTR3, TARDBP, and VCAM1) are cancer-related based on the Ingenuity knowledge database (http://www.ingenuity.com), but have not previously been shown to be associated with GISTs. The gene discussed is PAK2; the disease is cancer.